Detalhe da pesquisa
1.
Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma.
Int J Cancer
; 148(8): 1928-1937, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33152115
2.
Phase I study protocol: NKTR-255 as monotherapy or combined with daratumumab or rituximab in hematologic malignancies.
Future Oncol
; 17(27): 3549-3560, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154392
3.
NKTR-255 is a polymer-conjugated IL-15 with unique mechanisms of action on T and natural killer cells.
J Clin Invest
; 131(19)2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375310
4.
NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy.
J Immunother Cancer
; 9(5)2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34001523
5.
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma.
J Clin Oncol
; 39(26): 2914-2925, 2021 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255535
6.
Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02).
Cancer Discov
; 10(8): 1158-1173, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32439653
7.
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist.
Nat Commun
; 11(1): 660, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32005809
8.
Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.
Nat Commun
; 11(1): 661, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32005826
9.
A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rßγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors.
Cancer Discov
; 9(6): 711-721, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988166
10.
Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.
PLoS One
; 12(7): e0179431, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28678791
11.
Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.
Science
; 301(5641): 1895-8, 2003 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14512626